SUMMARY
The application of engineering theory and design to problems with in the biomedical community is not generally covered in traditional engineering curriculum. This course is intended to provide entry level graduate students with an introduction to the methods employed to solve the latest biomedical engineering problems. The scope and variety of the topics covered give students the opportunity to find a field of interest that may not have been obvious. 

 The course is designed to be a 3 QH lecture class with a coordinator to oversee the course while experts within that field teach individual topics.  1 to 2 weeks will be dedicated to each topic, leading to a minimum of 5 topics per quarter.

CLASS TIMES: MW 5 to 6:30pm
CLASS LOCATION: CMK  205
INSTRUCTORS: Paul Rullkoetter                 MET 104                    x-3512
                              Corinne Lengsfeld             CMK 204                    x-4843
TEXT: None

COURSE OUTLINE: 
Sept 8                     Course Introduction
Sept  10, 15 & 17   Introduction to Anatomy & Physiology [Dr. Rullkoetter]
Sept  22, 24 & 29   Biomechanics [Dr. Rullkoetter] 
Oct 1, 6 & 8           Biomaterials   [Dr. Rullkoetter]                   
Oct 13                    Exam I [Dr. Rullkoetter]
Oct 15                    Final Project assignment and discussion
Oct 20 & 22           Biofluids and Blood Substitutes [Dr. Lengsfeld]
Oct 27 & 29           Gene Therapy [Dr. Lengsfeld]
Nov 3                     Controlled Release Drug Delivery [Dr. Lengsfeld]
Nov 5 & 10            Pulmonary Delivery and Bioaerosols [Dr. Lengsfeld]
Nov 12                   Cell biology and Bioelectric Phenomena [Dr. Lengsfeld]
Nov 19                   Exam II [Dr. Lengsfeld]
Nov 21                   Project due
In addition to class times students will be required to attend seminars W 4-5pm that are specific to bioengineering [TBA]

FINAL PROJECT: (approval by end of 7th week, project due 5 pm March 15th)
Undergraduate students will produce a review paper on a specific bioengineering topic not fully covered by any course material (e.g., mechanical heart design). Topic areas will be selected by the students, but must be approved by one of the course instructors.  Comprehensive review papers are not short, will require extensive library research and will take more than 4 weeks to complete therefore students should plan accordingly.

Review paper format
Review papers must be clear, readily legible and conform to the following five requirements: 1) the height of the letters must not be smaller than 10 point; 2) type density must be no more than 15 characters per inch; 3) no more than 6 lines of type must be within a vertical inch; 4) margins of 2.5 cm along all edges; and 5) reviews are limited to approximately 3,000-4,000 words, including tables, and figures.

Review papers are well-focused, well-documented examinations of timely issues in the in bioengineering. The recommended format is below:

a. Abstract: The abstract should briefly (80-200 words) present, in one paragraph, the problem and experimental approach and state the major findings and conclusions. It should be self-explanatory and suitable for reproduction without rewriting. Footnotes or undefined abbreviations may not be used. If a reference must be cited, complete publication data must be given.
b. Introduction: Briefly sketch the background in the focus area, state the importance and health relevance of the research and outline the specific topics to be covered.
c. Main Body (subdivide in to suitable topics): Provides a comprehensive summary of the relevant research in the focus area. Critically evaluate the existing knowledge, and specifically identify the gaps which future research efforts should be directed.
d. References: List all references used to prepare the review. Each reference must include the title, names of all authors, book or journal, volume number, page numbers, and year of publication. The references should be limited to relevant and current literature.

Graduate students will produce a research proposal in NIH format on a bioengineering topic. Students can draw from their current graduate thesis topic area but the proposed work must be a new idea (as if a real proposal). Proposal topics must be approved by one of the course instructors. Competitive research proposals are not short, will require extensive library research and will take more than 4 weeks to complete therefore students should plan accordingly.

NIH Proposal Format 
Proposal must be clear, readily legible and conform to the following five requirements: 1) the height of the letters must not be smaller than 10 point; 2) Type density must be no more than 15 characters per inch; 3) No more than 6 lines of type must be within a vertical inch; 4) Margins of 2.5 cm along all edges; and 5) not exceed 25 pages. All tables, graphs, figures, diagrams, and charts must be included within the 25 page limit.

The recommended format is below:

a. Specific aims: List the broad, long-term objectives and what the specific research proposed in this application is intended to accomplish (one page recommended).
b. Background and Significance: Briefly sketch the background leading to the present application, critically evaluate existing knowledge, and specifically identify the gaps which the project is intended to fill. State concisely the importance and health relevance of the research described in this application by relating the specific aims to the broad, long-term objectives (2 to 4 pages recommended).
c. Preliminary Studies/Progress Report: Use this section to provide an account of the principal investigator’s (your) preliminary studies pertinent to the application information that will help to establish the experience and competence of the investigator to pursue the proposed project. Because you likely have no experimental or modeling data of your own to build on you will have to carry out rough calculations forming theoretical data to demonstrate the feasibility of your project.
d. Research Design and Methods: Describe the research design and the procedures to be used to accomplish the specific aims of the project. Include how the data will be collected, analyzed, and interpreted. Describe any new methodology and its advantage over existing methodologies. Discuss the potential difficulties and limitations of the proposed procedures and alternative approaches to achieve the aims. As part of this section, provide a tentative sequence or timetable for the project. 
e. Literature Cited: List all references. Each reference must include the title, names of all authors, book or journal, volume number, page numbers, and year of publication. The references should be limited